The "thing" Andy saddled me with (by way of Abbey) is no joke. Add seasonal allergies, and I sound like a pug! Even with being encumbered with these challenges, taking the Mekinst at night is a game-changer! I don't know why we didn't think of it.

Well, I do know why. We eat dinner late, and by waiting two hours after food, I'd be up going to bed later than I like, and my previous biorhythms were to wake up around 4:30 am to use the bathroom, and dosing at 4:30 seemed logical. Dinner can always be earlier, and drinking 60-90 oz of water daily (per Yale Pharmacy), a 4:30 am bathroom break comes much earlier. A week in, we haven't mastered earlier dinner, but the micro-fridge upstairs makes night dosing easier.

With the Mekinist having a window of eight hours where it actively kills tumor cells, (I like to think of it somewhere between The Cavern of the Evil Wizard [Big] and Pac Man), and the other 16 hours is recovery, night dosing, followed by sleep is the answer. I'm optimistic once I get over the sick hump, the new regimen will help me live a more normal life.